Trans-resveratrol, a flavonoid-like molecule found in grapes, mulberries, and other plants, mimics the healthy-aging effect of calorie restriction.* A significant decrease in the harmful effects of a high-fat, high-calorie diet was observed in mice, most likely due to increased fat metabolism from the up-regulation of the SIRT-1 enzyme, which acts as a cellular switch by both increasing the number of mitochondria and supporting their function.* SIRT-1 enzymes also have a positive impact on blood glucose metabolism, insulin sensitivity, and cell survival.* Thorne's PolyResveratrol-SR contains trans-resveratrol – along with synergistic plant extracts and a resveratrol metabolite that together optimize the metabolism and utilization of trans-resveratrol and enhance its numerous metabolic, cardioprotective, hepatoprotective, and healthy-aging properties.*

In addition to trans-resveratrol, the other ingredients in PolyResveratrol-SR include:
Pterostilbene: A naturally-occurring methylated metabolite of resveratrol. Pterostilbene exhibits optimal absorption and it is not as easily broken down in the liver.* Animal and in vitro studies indicate that while pterostilbene has healthy aging effects similar to resveratrol, it reaches higher levels in the blood and is longer lasting in the body.* Curcumin Phytosome, Green Tea Phytosome, and Quercetin Phytosome: Research shows quercetin slows the breakdown of resveratrol in the body, acts as a potent antioxidant, and is synergistic with the activities of resveratrol.* Green Tea Phytosome has a positive effect on fat metabolism, promotes optimal liver detoxification, and is very efficiently absorbed.* Curcumin Phytosome is significantly better absorbed than standardized curcumin extracts, and studies have found that it supports the body's normal inflammatory response by balancing cytokines and it demonstrates synergistic healthy-aging activity with resveratrol.*